Articoli scientifici

A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?

Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor nerve terminals and blocks the release of acetylcholine via the specific cleavage of the synaptosomal-associated protein of 25-kDa. Localized injections of BoNT/A are widely employed in clinical neurology to treat several human diseases characterized by muscle hyperactivity.

It is generally assumed that the effects of BoNT/A remain localized to the injection site. However, several  neurophysiological studies have provided evidence for central effects of BoNT/A, raising the issue of how these actions
arise. Here we review these data and discuss the possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits.

Keywords: botulinum neurotoxins, movement disorders, neuromuscular junction, retrograde axonal transport, synaptic transmission, synaptosomal-associated protein of 25-kDa.

(Fonte: Journal of Neurochemistry, 2009)

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